Pluriomics Stem Cell technology

Key Publications

 

2015

• Den Hartogh SC, Passier R. Fluorescent Reporters in Human Pluripotent Stem Cells: Contributions to Cardiac Differentiation and Their Applications in Cardiac Disease and Toxicity. Stem Cells. 2015 Oct 8.

• Van den Berg CW, Okawa S, Chuva de Sousa Lopes SM, van Iperen L, Passier R, Braam SR, Tertoolen LG, Del Sol A, Davis RP, Mummery CL. Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells. Development 2015 142(18):3231-8. Epub 2015. Jul 24.

• Birket MJ, Ribeiro MC, Verkerk AO, Ward D, Leitoguinho AR, den Hartogh SC, Orlova VV, Devalla HD, Schwach V, Bellin M, Passier R, Mummery CL.Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells. Nat Biotechnol. 2015 Sep;33(9):970-9

• Ribeiro MC, Tertoolen LG, Guadix JA, Bellin M, Kosmidis G, D’Aniello C, Monshouwer-Kloots J, Goumans M, Wang Y, Feinberg AW, Mummery CL, Passier R. Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro-Correlation between contraction force and electrophysiology. Biomaterials 2015 51, 138-150. Epub 2015 Feb 18 

• Van den Berg CW, Elliott DA, Braam SR, Mummery CL, Davis RP. Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions. Methods Mol Biol. 2015 Jan 28.

• Den Hartogh SC, Schreurs C, Monshouwer-Kloots JJ, Davis RP, Elliott DA, Mummery CL, Passier R. Dual reporter MESP1 mCherry/w-NKX2-5 eGFP/w hESCs enable studying early human cardiac differentiation. Stem Cells. 2015 Jan;33(1):56-67

 

2014

• Dambrot C, Braam SR, Tertoolen LG, Birket M, Atsma DE, Mummery CL. Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes. J Cell Mol Med. 2014 Aug;18(8):1509-18. doi: 10.1111/jcmm.12356. Epub 2014 Jul 1.

• Dambrot C, Buermans HP, Varga E, Kosmidis G, Langenberg K, Casini S, Elliott DA, Dinnyes A, Atsma DE, Mummery CL, Braam SR, Davis RP. Strategies for rapidly mapping proviral integration sites and assessing cardiogenic potential of nascent human induced pluripotent stem cell clones. Exp Cell Res. 2014 Oct 1;327(2):297-306. doi: 10.1016/j.yexcr.2014.05.001. Epub 2014 May 13.

• Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood-brain barrier in rats. Rip J, Chen L, Hartman R, van den Heuvel A, Reijerkerk A, van Kregten J, van der Boom B, Appeldoorn C, de Boer M, Maussang D, de Lange EC, Gaillard PJ. J Drug Target. 2014 Jun;22(5):460-7.

 

2013

• Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL. Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. Stem Cell Res. 2013 Jan;10(1):48-56. doi: 10.1016/j.scr.2012.08.007. Epub 2012 Sep 7

• Mizee MR, Wooldrik D, Lakeman KA, van het Hof B, Drexhage JA, Geerts D, Bugiani M, Aronica E, Mebius RE, Prat A, de Vries HE, Reijerkerk A. Retinoic acid induces blood-brain barrier development. J Neurosci. 2013 Jan 23;33(4):1660-71.

 

2012

• Kraushaar U, Meyer T, Hess D, Gepstein L, Mummery CL, Braam SR, Guenther E. Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models. Expert Opin Drug Saf. 2012 Mar;11(2):285-98 

• Reijerkerk A, Lakeman KA, Drexhage JA, van Het Hof B, van Wijck Y, van der Pol SM, Kooij G, Geerts D, de Vries HE. Brain endothelial barrier passage by monocytes is controlled by the endothelin system. J Neurochem. 2012 Jun;121(5):730-7.

 

2011

• Elliott DA, Braam SR, Koutsis K, Ng ES, Jenny R, Lagerqvist EL, Biben C, Hatzistavrou T, Hirst CE, Yu QC, Skelton RJ, Ward-van Oostwaard D, Lim SM, Khammy O, Li X, Hawes SM, Davis RP, Goulburn AL, Passier R, Prall OW, Haynes JM, Pouton CW, Kaye DM, Mummery CL, Elefanty AG, Stanley EG. NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat Methods. 2011 Oct 23;8(12):1037-40

• Davis RP, van den Berg CW, Casini S, Braam SR, Mummery CL. Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development. Trends Mol Med. 2011 Jun 22.

 

2010

• Braam SR, Mummery CL. Human stem cell models for predictive cardiac safety pharmacology Stem Cell Res. 2010 May;4(3):155-6.S.R. 

• Braam SR, L Tertoolen, A van de Stolpe, T Meyer, R Passier, C.L Mummery. Prediction of drug induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes – Stem Cell Research 2010 May;4(3):155-6

• Braam SR, Nauw R, Ward-van Oostwaard D, Mummery C, Passier R. Inhibition of ROCK improves survival of human embryonic stem cell-derived cardiomyocytes after dissociation. Ann N Y Acad Sci. 2010 Feb;1188:52-7. doi: 10.1111/j.1749-6632.2009.05083.x.

 

2009

 • Braam SR, R. Passier , C.L Mummery. Cardiomyocytes from human pluripotent stem cells in regenerative medicine and drug discovery. Trends in Pharmacological sciences 2009 Oct;30(10):536-45.

• Braam SR, D van Hoof, J Munoz, M.W. Pinkse, R. Linding, A.J.R Heck, C.L Mummery, J Krijgsveld. Phosphorylation dynamics during early differentiation of human embryonic stem cells Cell Stem Cell 2009 Aug 7

• Davis RP, Grandela C, Sourris K, Hatzistavrou T, Dottori M, Elefanty AG, Stanley EG, Costa M. Generation of human embryonic stem cell reporter knock-in lines by homologous recombination. Curr Protoc Stem Cell Biol. 2009

 

2008

• Braam SR (*), C Denning (*), E Matsa, L.E Young, R Passier, C.L Mummery. Feeder-free culture of human embryonic stem cells in conditioned medium for efficient genetic manipulation, Nature Protocols 2008;3(9):1435-43

• Braam SR, L.M Zeinstra, S.H.M Litjens, D Ward-van Oostwaard, S van den Brink, L.W van Laake, F Lebrin, R Passier, A Sonnenberg, C.L Mummery. Recombinant vitronectin is a functionally defined substrate that supports human embryonic stem cell self-renewal via αVβ5 integrin, Stem Cells 2008 Sep;26(9):2257-65.

• Graichen R, Xu X, Braam SR, Balakrishnan T, Norfiza S, Sieh S, Soo SY, Tham SC, Mummery C, Colman A, Zweigerdt R, Davidson BP. Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK. Differentiation. 2008 Apr;76(4):357-70. Epub 2007 Nov 15.

 

2005

• Moore JC, van Laake LW, Braam SR, Xue T, Tsang SY, Ward D, Passier R, Tertoolen LL, Li RA, Mummery CL. Human embryonic stem cells: genetic manipulation on the way to cardiac cell therapies. Reprod Toxicol. 2005 Sep-Oct;20(3):377-91.

 

2003

• Mummery C, Ward-van Oostwaard D, Doevendans P, Spijker R, van den BS, Hassink R, van der HM, Opthof T, Pera M, de la Riviere AB, Passier R, Tertoolen L. Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation 3-6-2003;107:2733-2740.

 

2002

• Shin CH, Liu ZP, Passier R, Zhang CL, Wang DZ, Harris TM, Yamagishi H, Richardson JA, Childs G, Olson EN. Modulation of cardiac growth and development by HOP, an unusual homeodomain protein. Cell 20-9-2002;110:725-735.

 

2000

 • Passier R, Zeng H, Frey N, Naya FJ, Nicol RL, McKinsey TA, Overbeek P, Richardson JA, Grant SR, Olson EN. CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo. J Clin Invest 2000;105:1395-1406